The NitroNox Plus is an FDA Cleared, Class II device to provide a mixture of N2O and O2, on demand, to a conscious, spontaneously breathing patient, under prescription use.  The NitroNox Plus is designed for use with adult and pediatric patients and is not intended to be used with infants or neonates (the FDA clearance letter may be downloaded below).

The NitroNox Plus (unlike the original NitroNox and other systems currently on the market) offers the highest level of SAFETY and EFFICACY because of several unique features, including:

Ability to titrate N2O from 0-70% providing significantly better reduction in pain and anxiety due to the analgesic and anxiolytic properties of N2O.

AUDIBLE ALARM that alerts the provider that either gas tank pressure is beginning to get low.

The audible alarm of the NitroNox Plus is a pleasing—but easy to hear—tone, not a startling buzzer.

Fail-safe shut off valves prevent any chance of N2O being delivered without O2.

NitroNox Plus also uniquely offers THREE gauges on the BODY of the device clearly displaying: (1) Mixed Gases Pressure, (2) O2 Pressure, and (3) N2O pressure.

A unique Function Test Button allowing providers to regularly confirm proper operation.

A unique Demand Valve with easy user access allowing unmatched serviceability.

A 50+ year track record of manufacturing safe N2O systems, made in the USA.

A unique Lock & Key mechanism to prevent unauthorized access to N20.

Unlike other systems available in the US, NitroNox Plus systems are available in fixed 50/50% and 0-50% and 0-70% systems.  All 3 options provide a simple to use device that help manage patients’ pain and anxiety during minimally invasive in-office procedures.

Work More Efficiently and Increase Treatment Acceptance:

Nitrous oxide and oxygen (N2O/O2) provides a safe, simple and fast-acting alternative to oral medications for minimal sedation. During the procedure, patients experience reduction in pain and anxiety due to the analgesic and anxiolytic properties of N2O.

Improve patient throughput:

• Nitrous oxide takes effect and is out of the patient’s system within a few minutes.
• Complete procedures more efficiently and effectively.
• Reduced recovery time and staffing during limited time monitor the patient.
• Patients return to normal activities quickly.

Improved patient care:

• Offer more ways to efficiently relax and provide comfort for your patients.
• Improve patient satisfaction scores, repeat treatments, and get more referrals.

Safety record:

• Nitrous oxide has been used for 100+ years and proven to be both effective and safe.
• Few side effects.
• Ease of administration.
• Patient self-administered.
• Analgesic and amnesiac properties.
• Equipment is cost effective and portable.

MEDICAL AESTHETICS procedures where N2O & O2 are used include:

• RF Microneedling / Skin Tightening (i.e. Morpheus(™) and Ultherapy(™))
• Neurotoxin injections
• Body contouring
• Dermal filler injections
• Non-invasive fat reduction
• Biopsies

UROLOGY procedures where N2O and O2 are used include:

• Vasectomy
• BPH treatment including
• UroLift® and Rezum(™)
• Cystoscopy
• Ultrasound
• Stent Removal
• Skin Treatments
• The Prolieve® System

OB/GYN procedures where N2O and O2 are used include:

• LEEP procedure
• Endometrial ablation
• Vaginal rejuvenation
• Labiaplasty
• Biopsies
• Hysteroscopy

REGENERATIVE MEDICINE procedures where N2O and O2 are used include:

• Joint injection
• Stem cell therapy
• PRP injection
• Vicosupplementation
• Venipuncture

Download #1:  NitroNox Plus FDA Clearance Letter

Download #2:  NitroNox Plus Product Brochure

Download #3:  NitroNox Plus Patient Brochure

Download #4:  NitroNox Plus Q&A